LIFE SCIENCES & MATERIALS

De novo protein sequence design

Task and verification

Generate candidate amino acid sequences for target 3D backbone structures and binding pockets. Downstream structural validation via ColabFold and ESMFold determines folding stability, target TM-score, and interface binding free energy.

Tools and runtime

Sequence generation + ColabFold/ESMFold structural validation & TM-score

OPENENV / PROTEIN

#protein-design#colabfold#structural-biology#folding

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